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* [[Nomenclature of Type III Secretion Systems|Nomenclature]] | * [[Nomenclature of Type III Secretion Systems|Nomenclature]] | ||
* [[Flagellar T3SS vs. virulence-associated T3SS]] | * [[Flagellar T3SS vs. virulence-associated T3SS]] | ||
* [[Injectisome | * [[Injectisome assembly]] | ||
</div> | </div> | ||
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<div class="mainpage_box"> | <div class="mainpage_box"> | ||
<h3>Subassemblies</h3><hr> | <h3>Subassemblies</h3><hr> | ||
* [[Needle | * [[Needle tip / translocon]] | ||
* [[Needle | * [[Needle filament]] | ||
* [[Base]] | * [[Base]] | ||
* [[Export | * [[Export apparatus]] | ||
* [[Cytoplasmic | * [[Cytoplasmic components]] | ||
</div> | </div> | ||
<div class="mainpage_box"> | <div class="mainpage_box"> | ||
<h3>T3SS | <h3>T3SS substrates</h3><hr> | ||
* [[Early | * [[Early substrates]] | ||
* [[Intermediate | * [[Intermediate substrates / translocators]] | ||
* [[Late | * [[Late substrates / effectors]] | ||
</div> | </div> | ||
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<div class="mainpage_box flex3"> | <div class="mainpage_box flex3"> | ||
<h3>Function</h3><hr> | <h3>Function</h3><hr> | ||
* [[Needle | * [[Needle length control]] | ||
* [[Substrate | * [[Substrate specificity switching]] | ||
* [[Host | * [[Host cell sensing]] | ||
* [[Targeting of | * [[Targeting of substrates]] | ||
</div> | </div> | ||
Revision as of 12:16, 30 April 2019
Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial effector proteins into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like Salmonella, Yersinia, enteropathogenic Escherichia coli (EPEC) or Pseudomonas. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or needle complex. This wiki aims at providing a comprehensive overview of all aspects of T3SS.
Organisms hosting virulence-associated T3SS
Function
Components of the T3SS injectisome
| 1 | SctC | Secretin |
| 2 | SctF | Needle filament protein |
| 3 | SctI | Needle adapter (inner rod) protein |
| 4 | SctJ | Inner inner ring protein |
| 5 | SctD | Outer inner ring protein |
| 6 | SctK | Accessory cytosolic protein |
| 7 | SctQ | Major sorting platform component |
| 8 | SctL | Stator |
| 9 | SctN | ATPase |
| 10 | SctO | Stalk |
| 11 | SctR | Minor export apparatus protein |
| 12 | SctS | Minor export apparatus protein |
| 13 | SctT | Minor export apparatus protein |
| 14 | SctU | Switch protein |
| 15 | SctV | Major export apparatus protein |
| 16 | SctE | Translocon protein |
| 17 | SctB | Translocon protein |
| 18 | SctA | Needle tip protein |
| 19 | SctP | Needle length regulator |
| 20 | SctW | Gatekeeper |