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Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial [[Effectors|effector proteins]] into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like ''Salmonella'', ''Yersinia'', enteropathogenic ''Escherichia coli'' (EPEC) or ''Pseudomonas''. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or [[needle complex]]. This wiki aims at providing a comprehensive overview of all aspects of T3SS.
Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial [[Effectors|effector proteins]] into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like ''Salmonella'', ''Yersinia'', enteropathogenic ''Escherichia coli'' (EPEC) or ''Pseudomonas''. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or [[needle complex]]. This wiki aims at providing a comprehensive overview of all aspects of T3SS.
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<h3>General concepts</h3><hr>
* [[Nomenclature of Type III Secretion Systems|Nomenclature]]
* [[Flagellar T3SS vs. virulence-associated T3SS]]
* [[Injectisome assembly]]
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<h3>Organisms hosting virulence-associated T3SS</h3><hr>
* ''[[Escherichia coli]]''
* ''[[Shigella spp.]]''
* ''[[Yersinia spp.]]''
* ''[[Salmonella spp.]]''
* ''[[Pseudomonas spp.]]''
* ''[[Ralstonia spp.]]''
* ''[[Xanthomonas spp.]]''
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<h3>Subassemblies</h3><hr>
* [[Needle tip / translocon]]
* [[Needle filament]]
* [[Base]]
* [[Export apparatus]]
* [[Cytoplasmic components]]
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<h3>T3SS substrates</h3><hr>
* [[Early substrates]]
* [[Intermediate substrates / translocators]]
* [[Late substrates / effectors]]
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<h3>Functional aspects</h3><hr>
* [[Needle length control]]
* [[Substrate specificity switching]]
* [[Host cell sensing]]
* [[Targeting of substrates]]
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<h3>Applied and translational topics</h3><hr>
* [[Biotechnological application of T3SS]]
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<div class="mainpage_box flex2"><h3>Latest T3SS Tweets</h3><hr>
{{#widget:Twitter}}
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<h2>Components of the T3SS injectisome</h2>
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[[File:T3SS Overview.png|frameless|548x548px]]
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{| class="wikitable"
{| class="wikitable"
|+Components of the T3SS injectisome
|1
|1
|SctC
|SctC
|Secretin
|[[Secretin]]
|-
|-
|2
|2
|SctF
|SctF
|Needle filament protein
|[[Needle filament|Needle filament protein]]
|-
|-
|3
|3
|SctI
|SctI
|Needle adapter (inner rod) protein
|[[Needle adapter|Needle adapter (inner rod) protein]]
|-
|-
|4
|4
|SctJ
|SctJ
|Inner inner ring protein
|[[Inner ring|Inner inner ring protein]]
|-
|-
|5
|5
|SctD
|SctD
|Outer inner ring protein
|[[Inner ring|Outer inner ring protein]]
|-
|-
|6
|6
|SctK
|SctK
|
|[[Accessory cytosolic protein]]
|-
|-
|7
|7
|SctQ
|SctQ
|Major sorting platform component
|[[Sorting platform|Major sorting platform component]]
|-
|-
|8
|8
|SctL
|SctL
|Stator
|[[Stator]]
|-
|-
|9
|9
|SctN
|SctN
|ATPase
|[[ATPase]]
|-
|-
|10
|10
|SctO
|SctO
|Stalk
|[[Stalk]]
|-
|-
|11
|11
|SctR
|SctR
|Minor export apparatus protein
|[[Export apparatus|Minor export apparatus protein]]
|-
|-
|12
|12
|SctS
|SctS
|Minor export apparatus protein
|[[Export apparatus|Minor export apparatus protein]]
|-
|-
|13
|13
|SctT
|SctT
|Minor export apparatus protein
|[[Export apparatus|Minor export apparatus protein]]
|-
|-
|14
|14
|SctU
|SctU
|Switch protein
|[[Switch protein]]
|-
|-
|15
|15
|SctV
|SctV
|Major export apparatus protein
|[[Export apparatus|Major export apparatus protein]]
|-
|-
|16
|16
|SctE
|SctE
|Translocon protein
|[[Translocon|Translocon protein]]
|-
|-
|17
|17
|SctB
|SctB
|Translocon protein
|[[Translocon|Translocon protein]]
|-
|-
|18
|18
|SctA
|SctA
|Needle tip protein
|[[Needle tip|Needle tip protein]]
|-
|-
|19
|19
|SctP
|SctP
|Needle length regulator
|[[Needle length regulator]]
|-
|-
|20
|20
|SctW
|SctW
|Gatekeeper
|[[Gatekeeper]]
|}
|}
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__NOTOC__

Latest revision as of 11:36, 20 September 2022

Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial effector proteins into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like Salmonella, Yersinia, enteropathogenic Escherichia coli (EPEC) or Pseudomonas. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or needle complex. This wiki aims at providing a comprehensive overview of all aspects of T3SS.

General concepts

Organisms hosting virulence-associated T3SS

Subassemblies

T3SS substrates

Functional aspects

Applied and translational topics

Latest T3SS Tweets


Components of the T3SS injectisome

T3SS Overview.png

1 SctC Secretin
2 SctF Needle filament protein
3 SctI Needle adapter (inner rod) protein
4 SctJ Inner inner ring protein
5 SctD Outer inner ring protein
6 SctK Accessory cytosolic protein
7 SctQ Major sorting platform component
8 SctL Stator
9 SctN ATPase
10 SctO Stalk
11 SctR Minor export apparatus protein
12 SctS Minor export apparatus protein
13 SctT Minor export apparatus protein
14 SctU Switch protein
15 SctV Major export apparatus protein
16 SctE Translocon protein
17 SctB Translocon protein
18 SctA Needle tip protein
19 SctP Needle length regulator
20 SctW Gatekeeper


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