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Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial [[Effectors|effector proteins]] into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like ''Salmonella'', ''Yersinia'', enteropathogenic ''Escherichia coli'' (EPEC) or ''Pseudomonas''. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or [[needle complex]]. This wiki aims at providing a comprehensive overview of all aspects of T3SS. | Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial [[Effectors|effector proteins]] into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like ''Salmonella'', ''Yersinia'', enteropathogenic ''Escherichia coli'' (EPEC) or ''Pseudomonas''. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or [[needle complex]]. This wiki aims at providing a comprehensive overview of all aspects of T3SS. | ||
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<h3>General concepts</h3><hr> | |||
* [[Nomenclature of Type III Secretion Systems|Nomenclature]] | |||
* [[Flagellar T3SS vs. virulence-associated T3SS]] | |||
* [[Injectisome assembly]] | |||
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<h3>Organisms hosting virulence-associated T3SS</h3><hr> | |||
* ''[[Escherichia coli]]'' | |||
* ''[[Shigella spp.]]'' | |||
* ''[[Yersinia spp.]]'' | |||
* ''[[Salmonella spp.]]'' | |||
* ''[[Pseudomonas spp.]]'' | |||
* ''[[Ralstonia spp.]]'' | |||
* ''[[Xanthomonas spp.]]'' | |||
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<h3>Subassemblies</h3><hr> | |||
* [[Needle tip / translocon]] | |||
* [[Needle filament]] | |||
* [[Base]] | |||
* [[Export apparatus]] | |||
* [[Cytoplasmic components]] | |||
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<h3>T3SS substrates</h3><hr> | |||
* [[Early substrates]] | |||
* [[Intermediate substrates / translocators]] | |||
* [[Late substrates / effectors]] | |||
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<h3>Functional aspects</h3><hr> | |||
* [[Needle length control]] | |||
* [[Substrate specificity switching]] | |||
* [[Host cell sensing]] | |||
* [[Targeting of substrates]] | |||
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<h3>Applied and translational topics</h3><hr> | |||
* [[Biotechnological application of T3SS]] | |||
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<div class="mainpage_box flex2"><h3>Latest T3SS Tweets</h3><hr> | |||
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<h2>Components of the T3SS injectisome</h2> | |||
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[[File:T3SS Overview.png|frameless|548x548px]] | |||
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{| class="wikitable" | {| class="wikitable" | ||
|1 | |1 | ||
|SctC | |SctC | ||
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|6 | |6 | ||
|SctK | |SctK | ||
| | |[[Accessory cytosolic protein]] | ||
|- | |- | ||
|7 | |7 | ||
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|[[Gatekeeper]] | |[[Gatekeeper]] | ||
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Latest revision as of 11:36, 20 September 2022
Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial effector proteins into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like Salmonella, Yersinia, enteropathogenic Escherichia coli (EPEC) or Pseudomonas. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or needle complex. This wiki aims at providing a comprehensive overview of all aspects of T3SS.
Organisms hosting virulence-associated T3SS
Functional aspects
Components of the T3SS injectisome
| 1 | SctC | Secretin |
| 2 | SctF | Needle filament protein |
| 3 | SctI | Needle adapter (inner rod) protein |
| 4 | SctJ | Inner inner ring protein |
| 5 | SctD | Outer inner ring protein |
| 6 | SctK | Accessory cytosolic protein |
| 7 | SctQ | Major sorting platform component |
| 8 | SctL | Stator |
| 9 | SctN | ATPase |
| 10 | SctO | Stalk |
| 11 | SctR | Minor export apparatus protein |
| 12 | SctS | Minor export apparatus protein |
| 13 | SctT | Minor export apparatus protein |
| 14 | SctU | Switch protein |
| 15 | SctV | Major export apparatus protein |
| 16 | SctE | Translocon protein |
| 17 | SctB | Translocon protein |
| 18 | SctA | Needle tip protein |
| 19 | SctP | Needle length regulator |
| 20 | SctW | Gatekeeper |