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Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial effector proteins into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like Salmonella, Yersinia, enteropathogenic Escherichia coli (EPEC) or Pseudomonas. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or needle complex. This wiki aims at providing a comprehensive overview of all aspects of T3SS.

General Concepts

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• Nomenclature
• Flagellar T3SS vs. Virulence-Associated T3SS

Organisms hosting T3SS

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• Escherichia coli
• Yersinia spp.
• Salmonella spp.
• Pseudomonas aeruginosa

Subassemblies

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• Needle Tip / Translocon
• Needle Filament
• Base
• Export Apparatus
• Cytoplasmic Components

T3SS Substrates

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• Early Substrates
• Intermediate Substrates / Translocators
• Late Substrates / Effectors

Function

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• Assembly
• Needle Length Control
• Substrate Specificity Switching
• Host Cell Sensing
• Targeting of Substrates

Latest T3SS Tweets

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Tweets by T3SS2

Components of the T3SS injectisome

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	1	SctC	Secretin
	2	SctF	Needle filament protein
	3	SctI	Needle adapter (inner rod) protein
	4	SctJ	Inner inner ring protein
	5	SctD	Outer inner ring protein
	6	SctK
	7	SctQ	Major sorting platform component
	8	SctL	Stator
	9	SctN	ATPase
	10	SctO	Stalk
	11	SctR	Minor export apparatus protein
	12	SctS	Minor export apparatus protein
	13	SctT	Minor export apparatus protein
	14	SctU	Switch protein
	15	SctV	Major export apparatus protein
	16	SctE	Translocon protein
	17	SctB	Translocon protein
	18	SctA	Needle tip protein
	19	SctP	Needle length regulator
	20	SctW	Gatekeeper