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Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial effector proteins into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like Salmonella, Yersinia, enteropathogenic Escherichia coli (EPEC) or Pseudomonas. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or needle complex. This wiki aims at providing a comprehensive overview of all aspects of T3SS.
Components of the T3SS injectisome
|
1 | SctC | Secretin |
| 2 | SctF | Needle filament protein | |
| 3 | SctI | Needle adapter (inner rod) protein | |
| 4 | SctJ | Inner inner ring protein | |
| 5 | SctD | Outer inner ring protein | |
| 6 | SctK | ||
| 7 | SctQ | Major sorting platform component | |
| 8 | SctL | Stator | |
| 9 | SctN | ATPase | |
| 10 | SctO | Stalk | |
| 11 | SctR | Minor export apparatus protein | |
| 12 | SctS | Minor export apparatus protein | |
| 13 | SctT | Minor export apparatus protein | |
| 14 | SctU | Switch protein | |
| 15 | SctV | Major export apparatus protein | |
| 16 | SctE | Translocon protein | |
| 17 | SctB | Translocon protein | |
| 18 | SctA | Needle tip protein | |
| 19 | SctP | Needle length regulator | |
| 20 | SctW | Gatekeeper |