Nomenclature of Type III Secretion Systems

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Historically, virulence-associated type III secretion systems have used organism specific names for system components. To facilitate communication between researchers working on different organisms, a unified nomenclature was proposed[1], comparable to the nomenclature used for flagella[2].

Functional Name T3SS family Ysc Inv-Mxi-Spa Ssa-Esc Hrp-Hrc 1 Hrp-Hrc 2
Sct name Flagellar homolog Yersinia Shigella Salmonella SPI-1 Salmonella SPI-2 E. coli P. syringae R. solanacearum
Secretin SctC - YscC MxiD InvG SsaC EscC HrcC HrcC
Pilotin SctG - YscW MxiM InvH - - - -
Needle filament protein SctF - YscF MxiH PrgI SsaG EscF HrpA HrpY
Needle adapter protein SctI - YscI MxiI PrgJ SsaI EscI HrpB HrpJ
Outer IM ring protein SctD - YscD MxiG PrgH SsaD EscD HrpQ HrpW
Inner IM ring protein SctJ FliF YscJ MxiJ PrgK SsaJ EscJ HrcJ HrcJ
Accessory cytosolic protein SctK - YscK MxiK OrgA - - HrpD -
Major sorting platform component SctQ FliMN YscQ Spa33 SpaO SsaQ EscQ HrcQA+B HrcQ
Stator SctL FliH YscL MxiN OrgB SsaK EscL HrpE HrpF
ATPase SctN FliI YscN Spa47 InvC SsaN EscN HrcN HrcN
Stalk SctO FliJ YscO Spa13 InvI SsaO Orf15 HrpO HrpD
Minor export apparatus protein SctR FliP YscR Spa24 SpaP SsaR EscR HrcR HrcR
SctS FliQ YscS Spa9 SpaQ SsaS EscS HrcS HrcS
SctT FliR YscT Spa29 SpaR SsaT EscT HrcT HrcT
Switch protein SctU FlhB YscU Spa40 SpaS SsaU EscU HrcU HrcU
Major export apparatus protein SctV FlhA YscV MxiA InvA SsaV EscV HrcV HrcV
Translocon protein SctE - YopB IpaB SipB SseC EspD HrpK PopF1,2
SctB - YopD IpaC SipC SseD EspB - -
Needle tip protein SctA - LcrV IpaD SipD - - - -
Needle length regulator SctP FliK YscP Spa32 InvJ SsaP EscP HrpP HpaP
Gatekeeper SctW - YopN MxiC InvE SsaL SepL HrpJ HpaA

References

  1. ↑ Hueck CJ. Type III protein secretion systems in bacterial pathogens of animals and plants. Microbiol Mol Biol Rev. 1998 Jun;62(2):379-433. PubMed PMID: 9618447.
  2. ↑ Iino T, Komeda Y, Kutsukake K, Macnab RM, Matsumura P, Parkinson JS, Simon MI, Yamaguchi S. New unified nomenclature for the flagellar genes of Escherichia coli and Salmonella Typhimurium. Microbiol Rev. 1988 Dec;52(4):533-5. PubMed PMID: 3070322.
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