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|1
|1
|SctC
|SctC
|Secretin
|[[Secretin]]
|-
|-
|2
|2
|SctF
|SctF
|Needle filament protein
|[[Needle filament|Needle filament protein]]
|-
|-
|3
|3
|SctI
|SctI
|Needle adapter (inner rod) protein
|[[Needle adapter|Needle adapter (inner rod) protein]]
|-
|-
|4
|4
|SctJ
|SctJ
|Inner inner ring protein
|[[Inner ring|Inner inner ring protein]]
|-
|-
|5
|5
|SctD
|SctD
|Outer inner ring protein
|[[Inner ring|Outer inner ring protein]]
|-
|-
|6
|6
Line 29: Line 29:
|7
|7
|SctQ
|SctQ
|Major sorting platform component
|[[Sorting platform|Major sorting platform component]]
|-
|-
|8
|8
|SctL
|SctL
|Stator
|[[Stator]]
|-
|-
|9
|9
|SctN
|SctN
|ATPase
|[[ATPase]]
|-
|-
|10
|10
|SctO
|SctO
|Stalk
|[[Stalk]]
|-
|-
|11
|11
|SctR
|SctR
|Minor export apparatus protein
|[[Export apparatus|Minor export apparatus protein]]
|-
|-
|12
|12
|SctS
|SctS
|Minor export apparatus protein
|[[Export apparatus|Minor export apparatus protein]]
|-
|-
|13
|13
|SctT
|SctT
|Minor export apparatus protein
|[[Export apparatus|Minor export apparatus protein]]
|-
|-
|14
|14
|SctU
|SctU
|Switch protein
|[[Switch protein]]
|-
|-
|15
|15
|SctV
|SctV
|Major export apparatus protein
|[[Export apparatus|Major export apparatus protein]]
|-
|-
|16
|16
|SctE
|SctE
|Translocon protein
|[[Translocon|Translocon protein]]
|-
|-
|17
|17
|SctB
|SctB
|Translocon protein
|[[Translocon|Translocon protein]]
|-
|-
|18
|18
|SctA
|SctA
|Needle tip protein
|[[Needle tip|Needle tip protein]]
|-
|-
|19
|19
|SctP
|SctP
|Needle length regulator
|[[Needle length regulator]]
|-
|-
|20
|20
|SctW
|SctW
|Gatekeeper
|[[Gatekeeper]]
|}
|}

Revision as of 08:08, 5 April 2019

Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial effector proteins into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like Salmonella, Yersinia, enteropathogenic Escherichia coli (EPEC) or Pseudomonas. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or needle complex. This wiki aims at providing a comprehensive overview of all aspects of T3SS.

Components of the T3SS injectisome
T3SS Overview.png 1 SctC Secretin
2 SctF Needle filament protein
3 SctI Needle adapter (inner rod) protein
4 SctJ Inner inner ring protein
5 SctD Outer inner ring protein
6 SctK
7 SctQ Major sorting platform component
8 SctL Stator
9 SctN ATPase
10 SctO Stalk
11 SctR Minor export apparatus protein
12 SctS Minor export apparatus protein
13 SctT Minor export apparatus protein
14 SctU Switch protein
15 SctV Major export apparatus protein
16 SctE Translocon protein
17 SctB Translocon protein
18 SctA Needle tip protein
19 SctP Needle length regulator
20 SctW Gatekeeper