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{{DISPLAYTITLE:Welcome to the T3SS Wiki}}
{{Main Page}}
 
Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial [[Effectors|effector proteins]] into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like ''Salmonella'', ''Yersinia'', enteropathogenic ''Escherichia coli'' (EPEC) or ''Pseudomonas''. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or [[needle complex]]. This wiki aims at providing a comprehensive overview of all aspects of T3SS.
{| class="wikitable"
|+Components of the T3SS injectisome
| rowspan="20" |[[File:T3SS Overview.png|frameless|548x548px]]
|1
|SctC
|[[Secretin]]
|-
|2
|SctF
|[[Needle filament|Needle filament protein]]
|-
|3
|SctI
|[[Needle adapter|Needle adapter (inner rod) protein]]
|-
|4
|SctJ
|[[Inner ring|Inner inner ring protein]]
|-
|5
|SctD
|[[Inner ring|Outer inner ring protein]]
|-
|6
|SctK
|
|-
|7
|SctQ
|[[Sorting platform|Major sorting platform component]]
|-
|8
|SctL
|[[Stator]]
|-
|9
|SctN
|[[ATPase]]
|-
|10
|SctO
|[[Stalk]]
|-
|11
|SctR
|[[Export apparatus|Minor export apparatus protein]]
|-
|12
|SctS
|[[Export apparatus|Minor export apparatus protein]]
|-
|13
|SctT
|[[Export apparatus|Minor export apparatus protein]]
|-
|14
|SctU
|[[Switch protein]]
|-
|15
|SctV
|[[Export apparatus|Major export apparatus protein]]
|-
|16
|SctE
|[[Translocon|Translocon protein]]
|-
|17
|SctB
|[[Translocon|Translocon protein]]
|-
|18
|SctA
|[[Needle tip|Needle tip protein]]
|-
|19
|SctP
|[[Needle length regulator]]
|-
|20
|SctW
|[[Gatekeeper]]
|}

Latest revision as of 20:05, 29 April 2019

Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial effector proteins into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like Salmonella, Yersinia, enteropathogenic Escherichia coli (EPEC) or Pseudomonas. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or needle complex. This wiki aims at providing a comprehensive overview of all aspects of T3SS.

General concepts

Organisms hosting virulence-associated T3SS

Subassemblies

T3SS substrates

Functional aspects

Applied and translational topics

Latest T3SS Tweets


Components of the T3SS injectisome

T3SS Overview.png

1 SctC Secretin
2 SctF Needle filament protein
3 SctI Needle adapter (inner rod) protein
4 SctJ Inner inner ring protein
5 SctD Outer inner ring protein
6 SctK Accessory cytosolic protein
7 SctQ Major sorting platform component
8 SctL Stator
9 SctN ATPase
10 SctO Stalk
11 SctR Minor export apparatus protein
12 SctS Minor export apparatus protein
13 SctT Minor export apparatus protein
14 SctU Switch protein
15 SctV Major export apparatus protein
16 SctE Translocon protein
17 SctB Translocon protein
18 SctA Needle tip protein
19 SctP Needle length regulator
20 SctW Gatekeeper


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