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Latest revision as of 11:36, 20 September 2022

Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial effector proteins into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like Salmonella, Yersinia, enteropathogenic Escherichia coli (EPEC) or Pseudomonas. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or needle complex. This wiki aims at providing a comprehensive overview of all aspects of T3SS.

General concepts

Organisms hosting virulence-associated T3SS

Subassemblies

T3SS substrates

Functional aspects

Applied and translational topics

Biotechnological application of T3SS

Latest T3SS Tweets

Tweets by T3SS2

Components of the T3SS injectisome

1	SctC	Secretin
2	SctF	Needle filament protein
3	SctI	Needle adapter (inner rod) protein
4	SctJ	Inner inner ring protein
5	SctD	Outer inner ring protein
6	SctK	Accessory cytosolic protein
7	SctQ	Major sorting platform component
8	SctL	Stator
9	SctN	ATPase
10	SctO	Stalk
11	SctR	Minor export apparatus protein
12	SctS	Minor export apparatus protein
13	SctT	Minor export apparatus protein
14	SctU	Switch protein
15	SctV	Major export apparatus protein
16	SctE	Translocon protein
17	SctB	Translocon protein
18	SctA	Needle tip protein
19	SctP	Needle length regulator
20	SctW	Gatekeeper

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-Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial [[Effectors|effector proteins]] into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like ''Salmonella'', ''Yersinia'', enteropathogenic ''Escherichia coli'' (EPEC) or ''Pseudomonas''. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or [[needle complex]].
+Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial [[Effectors|effector proteins]] into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like ''Salmonella'', ''Yersinia'', enteropathogenic ''Escherichia coli'' (EPEC) or ''Pseudomonas''. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or [[needle complex]]. This wiki aims at providing a comprehensive overview of all aspects of T3SS.
+<div class="mainpage_row">
+<div class="mainpage_column flex3">
+<div class="mainpage_box">
+<h3>General concepts</h3><hr>
+* [[Nomenclature of Type III Secretion Systems|Nomenclature]]
+* [[Flagellar T3SS vs. virulence-associated T3SS]]
+* [[Injectisome assembly]]
+</div>
+<div class="mainpage_box flex2">
+<h3>Organisms hosting virulence-associated T3SS</h3><hr>
+* ''[[Escherichia coli]]''
+* ''[[Shigella spp.]]''
+* ''[[Yersinia spp.]]''
+* ''[[Salmonella spp.]]''
+* ''[[Pseudomonas spp.]]''
+* ''[[Ralstonia spp.]]''
+* ''[[Xanthomonas spp.]]''
+</div>
+</div>
+<div class="mainpage_column flex3">
+<div class="mainpage_box">
+<h3>Subassemblies</h3><hr>
+* [[Needle tip / translocon]]
+* [[Needle filament]]
+* [[Base]]
+* [[Export apparatus]]
+* [[Cytoplasmic components]]
+</div>
+<div class="mainpage_box">
+<h3>T3SS substrates</h3><hr>
+* [[Early substrates]]
+* [[Intermediate substrates / translocators]]
+* [[Late substrates / effectors]]
+</div>
+</div>
+<div class="mainpage_column flex3">
+<div class="mainpage_box">
+<h3>Functional aspects</h3><hr>
+* [[Needle length control]]
+* [[Substrate specificity switching]]
+* [[Host cell sensing]]
+* [[Targeting of substrates]]
+</div>
+<div class="mainpage_box">
+<h3>Applied and translational topics</h3><hr>
+* [[Biotechnological application of T3SS]]
+</div>
+</div>
+<div class="mainpage_box flex2"><h3>Latest T3SS Tweets</h3><hr>
+{{#widget:Twitter}}
+</div>
+</div>
+<h2>Components of the T3SS injectisome</h2>
+<div class="mainpage_row" style="justify-content:flex-start">
+<div class="mainpage_box_frameless flex0">
+[[File:T3SS Overview.png|frameless|548x548px]]
+</div>
+<div class="mainpage_box_frameless flex0">
+{| class="wikitable"
+|1
+|SctC
+|[[Secretin]]
+|-
+|2
+|SctF
+|[[Needle filament|Needle filament protein]]
+|-
+|3
+|SctI
+|[[Needle adapter|Needle adapter (inner rod) protein]]
+|-
+|4
+|SctJ
+|[[Inner ring|Inner inner ring protein]]
+|-
+|5
+|SctD
+|[[Inner ring|Outer inner ring protein]]
+|-
+|6
+|SctK
+|[[Accessory cytosolic protein]]
+|-
+|7
+|SctQ
+|[[Sorting platform|Major sorting platform component]]
+|-
+|8
+|SctL
+|[[Stator]]
+|-
+|9
+|SctN
+|[[ATPase]]
+|-
+|10
+|SctO
+|[[Stalk]]
+|-
+|11
+|SctR
+|[[Export apparatus|Minor export apparatus protein]]
+|-
+|12
+|SctS
+|[[Export apparatus|Minor export apparatus protein]]
+|-
+|13
+|SctT
+|[[Export apparatus|Minor export apparatus protein]]
+|-
+|14
+|SctU
+|[[Switch protein]]
+|-
+|15
+|SctV
+|[[Export apparatus|Major export apparatus protein]]
+|-
+|16
+|SctE
+|[[Translocon|Translocon protein]]
+|-
+|17
+|SctB
+|[[Translocon|Translocon protein]]
+|-
+|18
+|SctA
+|[[Needle tip|Needle tip protein]]
+|-
+|19
+|SctP
+|[[Needle length regulator]]
+|-
+|20
+|SctW
+|[[Gatekeeper]]
+|}
+</div>
+</div>
+__NOTOC__