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Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial [[Effectors|effector proteins]] into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like ''Salmonella'', ''Yersinia'', enteropathogenic ''Escherichia coli'' (EPEC) or ''Pseudomonas''. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or [[needle complex]]. This wiki aims at providing a comprehensive overview of all aspects of T3SS. | Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial [[Effectors|effector proteins]] into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like ''Salmonella'', ''Yersinia'', enteropathogenic ''Escherichia coli'' (EPEC) or ''Pseudomonas''. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or [[needle complex]]. This wiki aims at providing a comprehensive overview of all aspects of T3SS. | ||
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<h3>General Concepts</h3><hr> | |||
* [[Nomenclature]] | |||
* [[Flagellar T3SS vs. Virulence-Associated T3SS]] | |||
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<h3>Organisms hosting T3SS</h3><hr> | |||
* ''[[Escherichia coli]]'' | |||
* ''[[Yersinia spp.]]'' | |||
* ''[[Salmonella spp.]]'' | |||
* ''[[Pseudomonas aeruginosa]]'' | |||
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<h3>Subassemblies</h3><hr> | |||
* [[Needle Tip / Translocon]] | |||
* [[Needle Filament]] | |||
* [[Base]] | |||
* [[Export Apparatus]] | |||
* [[Cytoplasmic Components]] | |||
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<h3>T3SS Substrates</h3><hr> | |||
* [[Early Substrates]] | |||
* [[Intermediate Substrates / Translocators]] | |||
* [[Late Substrates / Effectors]] | |||
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<h3>Function</h3><hr> | |||
* [[Assembly]] | |||
* [[Needle Length Control]] | |||
* [[Substrate Specificity Switching]] | |||
* [[Host Cell Sensing]] | |||
* [[Targeting of Substrates]] | |||
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<div class="mainpage_box"><h3>Latest T3SS Tweets</h3><hr> | |||
{{#widget:Twitter}} | |||
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<div class="mainpage_box flex2"><h3>Components of the T3SS injectisome</h3><hr> | <div class="mainpage_box flex2"><h3>Components of the T3SS injectisome</h3><hr> | ||
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|[[Gatekeeper]] | |[[Gatekeeper]] | ||
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Revision as of 09:54, 30 April 2019
Virulence-associated type III secretion systems (T3SS) serve the injection of bacterial effector proteins into eukaryotic host cells to manifest bacterial colonization and infection. Consequently, these systems are essential factors for the virulence of numerous animal and plant pathogens like Salmonella, Yersinia, enteropathogenic Escherichia coli (EPEC) or Pseudomonas. The macromolecular machine mediating secretion and injection of effector proteins is called injectisome or needle complex. This wiki aims at providing a comprehensive overview of all aspects of T3SS.
Function
Components of the T3SS injectisome
|
1 | SctC | Secretin |
| 2 | SctF | Needle filament protein | |
| 3 | SctI | Needle adapter (inner rod) protein | |
| 4 | SctJ | Inner inner ring protein | |
| 5 | SctD | Outer inner ring protein | |
| 6 | SctK | ||
| 7 | SctQ | Major sorting platform component | |
| 8 | SctL | Stator | |
| 9 | SctN | ATPase | |
| 10 | SctO | Stalk | |
| 11 | SctR | Minor export apparatus protein | |
| 12 | SctS | Minor export apparatus protein | |
| 13 | SctT | Minor export apparatus protein | |
| 14 | SctU | Switch protein | |
| 15 | SctV | Major export apparatus protein | |
| 16 | SctE | Translocon protein | |
| 17 | SctB | Translocon protein | |
| 18 | SctA | Needle tip protein | |
| 19 | SctP | Needle length regulator | |
| 20 | SctW | Gatekeeper |